Faliraki is one of the best places to head if you want action in Rhodes. There are tons of good restaurants and bars that never seem to shut. Chaplin's, located in the main beach area, is one of the oldest bars in town and it offers some of the best entertainment - top DJs from England can regularly be spotted working the turntables.
On a more sophisticated note, the Odyssey Café-Bar is the place to go for spine-tingling cocktails and a romantic night out. The Sting raises the temperature somewhat - this bar plays excellent music and is always filled with a buzzing crowd. Restaurant-wise Sarantis on the main road is one of the finest.